Abstract
The stems of Clerodendron trichotomum have been traditionally used for treatment of hypertension in far East Asia including China, Korea, and Japan. Bioassay-guided fractionation and purification of the EtOAc-soluble extract of Clerodendron trichotomum afforded acteoside ( 1), leucosceptoside A ( 2), martynoside ( 3), acteoside isomer ( 4), and isomartynoside ( 5). The angiotensin converting enzyme (ACE) activities were significantly inhibited by the addition of these phenylpropanoid glycosides ( 1– 5) in a dose-dependent manner of which IC 50 values were 373±9.3 μg/ml, 423±18.8 μg/ml, 524±28.1 μg/ml, 376±15.6 μg/ml, 505±26.7 μg/ml, respectively. These results suggest that the antihypertensive effect of Clerodendron trichotomum may be, at least in part, due to ACE inhibitory effect of phenylpropanoid glycosides.
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