Abstract
Background Circulating angiotensin-2 levels (A2) protect the circulation against sudden falls in blood pressure. A2 is generated by the enzymatic action of angiotensin converting enzyme (ACE) on angiotensin-1. The ACE genes have 2 allellic forms, with the presence ‘I’ or absence ‘D’ of a 287 base pair intron of the gene. The deletion ‘DD’ genotype is associated with high A2 generation & higher serum ACE levels, while the insertion ‘I I’ with lower serum ACE levels & ACE activity.
Highlights
Circulating angiotensin-2 levels (A2) protect the circulation against sudden falls in blood pressure
Aim To examine whether these 2 inherited polymorphisms have a different profile in patients with past anaphylaxis we compared this with control groups which included the measurement of serum angiotensin converting enzyme (ACE) levels
No statistical differences were found between ‘Atopics’ & Healthy controls (HC), but significant differences in the genotype frequency were seen between subjects with anaphylaxis and HC
Summary
Circulating angiotensin-2 levels (A2) protect the circulation against sudden falls in blood pressure. Angiotensin converting enzyme-gene polymorphisms in normal subjects, atopic individuals and those with anaphylaxis to venom, food and drugs The deletion ‘DD’ genotype is associated with high A2 generation & higher serum ACE levels, while the insertion ‘I I’ with lower serum ACE levels & ACE activity.
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