Abstract
[Purpose]Recent studies have demonstrated a probable association between ACE I/D polymorphism and obesity. Thus, this study aimed to investigate whether ACE I/D polymorphism influenced the susceptibly of developing obesity in Korean adults.[Methods]A total of 353 healthy Korean adults aged between 30 and 82 years were recruited, including 157 males and 196 females. Among the participants, 103 (29.2 %) were classified as normal (BMI < 23 kg/m2), 117 (33.1 %) as overweight (23 kg/m2 ≤ BMI < 25 kg/m2), and 133 (37.7 %) as obese (BMI ≥ 25 kg/m2). ACE polymorphism (rs1799752) analysis was performed using the MGB TaqMan® SNP Genotyping assay with 3 types of primers and 2 types of probes. The distributions of the ACE genotypes and allele frequencies were analyzed among the three groups using the Hardy-Weinberg equilibrium, chi-square tests, and multiple regression analysis.[Results]The distribution of the ACE genotypes were as follows: normal [II: n=38 (36.9 %), ID: n=46 (36.8 %), DD: n=19 (18.4 %)], overweight [II: n=43 (36.8 %), ID: n=55 (47.0 %), DD: n=19 (16.2 %)], and obese [II: n=41 (30.8 %), ID: n=76 (57.0 %), DD: n=16 (12.0 %)]. Unexpectedly, the I allele, rather than the D allele, was common in the obese group.[Conclusion]ACE I/D polymorphism is not associated with BMI in Korean adults. Thus, it is unlikely to be a powerful candidate gene for obesity in Korean adults.
Highlights
Obesity, defined as an abnormal or excessive accumulation of body fat, has become a global pandemic with a high prevalence in both adults and children[1]
The criteria for categorization of the BMI of Korean adults was adopted in accordance with the 2018 guideline for the management of obesity that was provided by the Korean Society for the Study of Obesity (KSSO)[31]
SBP increased with the increase in fat storage
Summary
Obesity, defined as an abnormal or excessive accumulation of body fat, has become a global pandemic with a high prevalence in both adults and children[1]. Obesity is a direct and/or indirect risk factor for metabolic syndrome, a collection of pathological conditions comprising of abdominal obesity, dyslipidemia, hyperglycemia and hypertension[2]. It is associated with a greater burden of disease, including a continuous increase in morbidity and mortality[3]. Genetic factors or obesity-related genes, are targeted for prevention strategies[4,5], whereas treatment strategies rely on environmental factors including excessive food intake, physical inactivity, and stress[6,7]. Obesogenic effects of candidate gene polymorphisms have been recently demonstrated[4,5,8]
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