Abstract
In order to verify the association of Angiotensin converting enzyme (ACE) gene with different kinds of dementia, as well as its association with APO-E (genotype), we performed ACE genotyping in subjects with late-onset probable Alzheimer's disease (LOAD, n=64), early-onset probable Alzheimer's disease (EOAD, n=32), possible Alzheimer's disease (pAD, n=44), vascular dementia (VD, n=12), age-associated memory impairment (AAMI, n=15) and 40 healthy age-matched controls, who were previously characterized for APO-E. After the principal component analysis ACE D and Apo-Eϵ 4 alleles disclosed the highest prevalence in the cognitively impaired groups of subjects, Apo-Eϵ 4 being more specific for LOAD and pAD. ACE D allele seems to be an unspecific susceptibility factor for mental decline.
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