Abstract
In this project work, Garcinia cambogia seeds extract was prepared and analysed for inhibitory studies. G. cambogia or the Malabar tamarind, commonly used as a food preservative, flavouring agent or food-bulking agent, and as a traditional remedy to treat constipation, piles, rheumatism, edema, irregular menstruation and intestinal parasites in many Asian countries. G. cambogia seeds solvents (Methanol, ethylacetate, petroleum ether and acetone) extract were prepared and pharmacological activities were analyzed such as antioxidant activity, ACE inhibitory and trypsin inhibitory activities. Among the extracts tested, methanolic extract of G. cambogia has shown potent antioxidant, angiotensin converting enzyme and trypsin inhibitory activities.
Highlights
Studies have shown that many of these antioxidant compounds possess anti-inflammatory, antiatherosclerotic, antitumor, antimutagenic, anticarcinogenic, antibacterial and antiviral activities
The kidney acetone powder was dissolved in 300 mM sodium borate buffer in the ratio of 1:10, centrifuged and supernatant served as crude enzyme
In our project work angiotensin converting enzyme (ACE) was partially purified from porcine kidney by employing ammonium sulphate precipitation technique
Summary
Studies have shown that many of these antioxidant compounds possess anti-inflammatory, antiatherosclerotic, antitumor, antimutagenic, anticarcinogenic, antibacterial and antiviral activities. The natural plant based antioxidants play an important role in the maintenance of human health (Branen et al, 1975) Synthetic antioxidants such as butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) have been used as antioxidants since the beginning of this century. Garcinia cambogia has a limited native global distribution, being restricted to India, Nepal and Sri Lanka, but it has been introduced elsewhere where it is distributed in the subtropical region of Asia including China, Malaysia and the Philipines. These trees are found mainly in the semi-evergreen to evergreen forests of Southwest India, predominantly in the Western Ghats (Maharashtra, Karnataka, Kerala and Tamil Nadu). In background of the above mentioned properties associated with G. cambogia seeds, this study has been taken up to evaluate scientifically the pharmacological properties of study the effect of solvent extract on antioxidant, ACE and trypsin activities
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