Abstract
The polymorphisms of ACE gene has been investigated using polymerase chain reaction for detection of ACE I/D genotype frequency in hypertensive cases in sector of Egyptian population. Serum ACE is significant higher in hypertensive group than normotensive one (27.5± 4.4 and 21.3± 5.4 ng/m respectively. Means SBP (systolic blood pressure), DBP (diastolic blood pressure) and urinary protein excretion in DD genotype were 181±17 mmHg, 112±19mmHg, 38±4.8mg/dl and 141.5± 36.8mg/24h respectively but, in II genotype were 142± 10 mmHg, 99± 13 mmHg, 43.5±4 mg/dl and 116.4± 36 mg/24h respectively. In hypertensive patients, serum ACE levels in DD, ID and II genotypes were 36.2± 5.7, 22.1± 3.7 and 24.5± 4.9 respectively. D/D ACE gene polymorphism plays a role in the development of target organ damage in sever essential hypertension and might have a prognostic value. It can be considered as one of risk factor of hypertension.
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