Abstract
The effects of angiotensin and metaraminol on myocardial uptake of 3H-norepinephrine in the isolated perfused heart and the in vivo effects of angiotensin on myocardial norepinephrine levels were studied. Inhibition of 3H-norepinephrine uptake resulted with angiotensin and metaraminol administration. Immediately after the administration of angiotension in vivo, endogenous myocardial norepinephrine levels were transiently increased. This increase in myocardial norepinephrine content was inversely related to the dose of angiotensin administered and was abolished by acute bilateral adrenalectomy. Angiotensin-induced stimulation of catecholamine release was investigated in the isolated, retrograde perfused adrenal. Dose-dependent stimulation of adrenal catecholamine secretion was observed. The data substantiate the ability of angiotensin to modulate sympathoadrenal function.
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