Abstract
Angiotensin-(1-7) is a vasoactive heptapeptide of renin-angiotensin system which is usually produced by angiotensin converting enzyme 2 and exhibits activity through activation of Mitochondrial assembly (Mas) receptor. In present scenario, the Ang-(1-7)/ACE2/Mas axis has tendency to counterbalance many vasoconstrictor biomolecules such as classical renin angiotensin system that includes ACE, ANG, renin, AT1 and AT2 receptors. Ang (1-7) is a vasodilator substance that shows significant roles in cardiovascular system. Because of the protective roles of Ang-(1-7) in cardiomyocytes and endothelial tissues, it is also known to evoke anti- arrhythmogenic effects as well as endogenous inducer for the release of vasodilators like nitric oxide and prostanoids. Moreover, the heptapeptide Ang-(1-7) is also being explored against organ failure, renal diseases, preeclampsia and even against carcinoma. This review circumscribes many pharmacological potentials of Ang-(1-7) against various physiological conditions.
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