ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA: A CASE REPORT OF A RARE BENIGN VASCULAR TUMOR

Abstract

Oral vascular lesions present a variety of clinicopathologic aspects and often lead to diagnostic difficulties. We describe the case of a 27-year-old male patient referred to our service for evaluation of an asymptomatic lesion in the oral cavity. Intraoral examination revealed a sessile, red nodule of soft consistency in lateral border of tongue, measuring approximately 0.5 cm in diameter. Based on clinical diagnosis of inflammatory fibrous hyperplasia, an excisional biopsy was performed. Histopathologic analysis revealed a benign vascular lesion characterized by proliferation of epithelioid endothelial cells, mostly constituting small-caliber tortuous blood vessels. Mononuclear inflammatory infiltrate with remarkable presence of eosinophils was also evident. Proliferating cells demonstrated diffuse immunopositivity for CD31, CD34, and S100. These findings led to the histopathologic diagnosis of angiolymphoid hyperplasia with eosinophilia. This report emphasizes the importance of knowledge regarding clinicopathologic features of oral vascular lesions for a correct diagnosis and management of the patient.