Abstract
To assess the pro-angiogenic activity of Euphorbia tirucalli, commonly known as "avelós" plant, we performed a series of tests by applying an aqueous E. tirucalli latex solution (10 mg/mL) to the chorioallantoic membranes (CAMs) of 80 fertilized chicken eggs incubated in a temperature- and humidity-controlled automatic incubator. The results indicated that the aqueous latex solution increased vascular network formation compared to that with the negative control (p < 0.05) and the inhibitor control (p < 0.05). This suggests that under the experimental conditions tested, the aqueous latex solution induced an inflammatory response leading to neoangiogenesis.
Highlights
Angiogenesis is defined as the formation of new blood vessels from pre-existing capillary vessels, involving a series of coordinated events: proliferation of endothelial cells, migration of cells to distal points, cell realignment, vessel formation, and production of a new basement membrane (Folkman, 1976; Folkman and Ingber, 1992)
Compared to the negative control (p < 0.05) and the inhibitor control (p < 0.05) groups, the groups treated with the E. tirucalli latex aqueous solution showed increased neoangiogenesis
Medicinal plants are commonly used for therapeutic purposes in traditional medicine, and a variety of plants with potential pharmaceutical properties that are found in Brazil contribute to an increased consumption of phytotherapeutic products (Gurib-Fakim, 2006; Castro et al, 2004)
Summary
Angiogenesis is defined as the formation of new blood vessels from pre-existing capillary vessels, involving a series of coordinated events: proliferation of endothelial cells, migration of cells to distal points, cell realignment, vessel formation, and production of a new basement membrane (Folkman, 1976; Folkman and Ingber, 1992). It occurs in physiologic processes such as menstruation, ovulation, and wound healing.
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