Abstract
Objective: To analyze angiogenesis in the post-extracted tooth of Wistar rats after application of okra ( Abelmoschus esculentus ) extract. Material and Methods: A total of 18 rats were divided into two groups (control and treatment). Okra extract with a concentration of 30% in gel form was applied on the post-extraction socket of the treatment group. The rats were sacrificed on day-3, day-5, and day-7 after tooth extraction. The newly-formed blood vessels were counted and statistically analyzed by means of One Way ANOVA and Tukey HSD with a significance level set at 5%. Results: The newly-formed capillaries of the control group (4.67 ± 1.53) on day-3 were lower than the treatment group (9.00 ± 1.00). The newly-formed capillaries recorded from the control group, both in day-5 (9.33 ± 1.53) and day-7 (8.67 ± 1.53) were lower than the treatment group, which started to decreased from day-5 (13.67 ± 1.53) to day-7 (12.33 ± 0.58). Significant differences were found in treatment group, on day-3 compared to day-5 (p=0.005), and on day-3 to day-7 (p=0.024) . Conclusion: Okra extract in gel form at 30% concentration can increase the angiogenesis during the wound healing process of the extracted tooth on Wistar rats.
Highlights
Angiogenesis constitutes the new blood vessels formation from the pre-existing blood vessels, which is required in the wound healing process
The newly-formed capillaries recorded from the control group, both in day-5 (9.33 ± 1.53) and day-7 (8.67 ± 1.53) were lower than the treatment group, which started to decreased from day-5 (13.67 ± 1.53) to day-7 (12.33 ± 0.58)
This study is aiming to analyze the efficacy of okra fruit extract in gel form at 30% concentration toward the post-extraction wound healing process
Summary
Angiogenesis constitutes the new blood vessels formation from the pre-existing blood vessels, which is required in the wound healing process. This physiological response initiated by the activation of endothelial cells in the inner lining of blood vessels mediated by proangiogenic factors and hypoxic environment. Tooth extraction is a procedure of removing a tooth from its socket. The process may cause damage, both the hard and soft tissues, trigger the physiological response of the wound healing process [2]. An ideal tooth extraction should be able to remove the whole tooth without pain and with minimal trauma of the adjacent tissues to allow the normal wound healing without any complication. Complications of tooth extraction may appear, such as pain, infection, severe bleeding, and dry socket [3]
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