Abstract
Angiogenesis as a prognostic factor of pathological stage IA lung adenocarcinoma: developing an angiogenic score
Highlights
Tumours, like normal tissues, need a constant supply of nutrients and O2, as well as the elimination of metabolic residue and CO2, which is why they induce angiogenesis
microvascular density (MVD) was categorised at an optimum cut-off point of three markers, with 192 vessels/mm2 for CD34, and 339 vessels/mm2 for CD31 which coincided with the mean
A survival analysis was done, and a comparison was made of the curves between the “low MVD” and the “high MVD” of each marker, which were compared by the log-rank method (Figure 1)
Summary
Like normal tissues, need a constant supply of nutrients and O2, as well as the elimination of metabolic residue and CO2, which is why they induce angiogenesis. According to world data that have recently become available, LC is the most frequently diagnosed neoplasia that causes most deaths worldwide. Despite recent advances, this disease still has a bad prognosis with survival below 19% [1,4,5]. Adenocarcinoma (ADC) is the most frequent histological subtype among non-small lung cancers (NSLC) and is the most variable and heterogeneous form of LC. This seems to be one of the determining reasons why different clinical behaviours appear in patients with the same tumour stage. It has become a relevant focal point to investigate different prognostic factors to classic TNM in an attempt to improve directed therapies and survival [6]
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