Abstract
A key-hallmark of cancer is the promotion of angiogenesis. While there are currently no markers of the net angiogenic activity of prostate cancer (PCa) that can help investigators to design specific anti-angiogenic strategies, it is reasonable to assume that the quantification of various aspects of tumor vasculature may provide an indication of angiogenic activity. It has been ascertained that malignant tumors can generate their vasculature in seven distinct ways, including sprouting angiogenesis, vasculogenesis, intussusceptive angiogenesis, vascular co-option, mosaic vessels, vasculogenic mimicry and trans-differentiation of cancer stem-like cells into tumor endothelial cells. Here we briefly review these ways to get blood supply for the progression of PCa, its predictive and prognostic role and the actual discrepancies in the quantitative evaluation of neovascularity.
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