Abstract
Angina pectoris or coronary thrombosis were personally observed in 20 fathers and 21 sons. It was found that the first evidence of coronary disease in the sons appeared at an age 13.1 years younger (48.1 years) than that of the fathers (61.2 years). The average age at death of 8 sons was 54.8 years, and that of 14 fathers was 68.7 years, i.e., a difference of 13.9 years. The duration of coronary symptoms in the dead sons was 7.5 years, and that in the dead fathers was 9.2 years. The possibility of statistical errors in this type of study was discussed. The evidence suggests that some factors are at work which cause coronary artery disease to appear at a younger age and run a more severe course in the present than in the previous generation.
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