Abstract
The aneuploidy inducing activity of a Chinese medicinal herb,Tripterygium hypoglaucum (level) Hutch (THH) were investigated by means of three cytogenetic end points, namely C-mitotic (CM) effects, micronucleus (MN) and parallel chromosome structural aberration (CA) analysesin vivo. The experiments were performed on mouse bone marrow cells. THH showed similar genotoxic effects to colchicine (COL) in CM, MN and CA analyses; positive CM effects were observed accompanied with increases of mitotic index and frequencies of C-mitotic cells as well as decreased frequencies of anaphase in all of the THH-treated groups. The compound showed a positive MN response in bone marrow polychromatic erythrocytes but was negative in CA analyses. The preliminary results suggested that THH is an aneuploidy inducer in mouse bone marrow cells under present experiment conditions.
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