Abstract
AbstractMouse embryos were collected from females derived from fourway crosses between inbred strains; the females were each treated with a single ip injection of 1, 0.1, or 0.01 μg diethylstilbestrol diphosphate 6, 24, or 48 h before being killed at day 8.5 of gestation. Chromosome counts from ten metaphase plates from each of 307 embryos recovered from 45 experimental females were compared with counts from103 embryos from 15 controls, which had received injections of 0.85% saline. Statistical analysis of the data revealed that both increases in dose and time of exposure were instrumental in producing aneuploid cells. Analysis of treatment means showed that as either dose or exposure time was increased, the rate of aneuploidy was significantly increased.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
