Aneuploidy data review committee: Summary compilation of chemical data base and evaluation of test methodology

Abstract

The Aneuploidy Data Review Commi.'ttee is composed of 9 working groups on different aneuploidy test systems (Dellarco et al., 1986); the reports of these working groups comprise the major part of this special issue of Mutation Research. This paper summarizes the conclusions of the committee and the data base of chemical test results. The data base on aneuploidy induction is too small at present for detailed comparisons of assay systems or assessments of chemical activity, but this systematic, critical reveiw of methodology provides guidelines for further test development and validation.