Abstract
The bilateral injection of 1–2 μl of 5% procaine hydrochloride into the sulcal prefrontal cortex of the rat attenuated self-stimulation of the lateral hypothalamus and of the pontine tegmentum. The attenuation was measured by a decrease in rate or cessation of self-stimulation and by an increased threshold for steady self-stimulation. Unilateral injections or bilateral injections more than 1–2 mm from the sulcal prefrontal cortex, were ineffective in blocking brain-stimulation reward. Electrical stimulation of the sulcal prefrontal cortex produced brain-stimulation reward. It had previously been shown that neurons in the sulcal (and medial) prefrontal cortex are activated during self-stimulation of many different reward sites. It is concluded that a region in or near the sulcal prefrontal cortex is involved in brain-stimulation reward.
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