Abstract
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and organ ischemia linked to disseminated microvascular platelet rich-thrombi. TTP is specifically related to a severe deficiency of ADAMTS13, a cleaving protease for von Willebrand (vWF).
Highlights
thrombocytopenic purpura (TTP) is characterized by formation of plateletrich thrombi in both the arterial and capillary microvasculature, resulting in thrombocytopenia and micro angiopathic hemolytic anemia (MAHA)
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and organ ischemia linked to disseminated microvascular platelet rich-thrombi
We present 40-yr-old parturient with TTP who underwent spinal anesthesia for cesarean delivery at 37 weeks of gestation
Summary
TTP is characterized by formation of plateletrich thrombi in both the arterial and capillary microvasculature, resulting in thrombocytopenia and micro angiopathic hemolytic anemia (MAHA). A 40-year-old pregnant patient at 37 weeks of gestation, BMI 27.88 (67 kg weight, 155 cm height) diagnosed with TTP, submitted to our hospital for a scheduled cesarean section. PLT < 50,000 μL Pre-eclampia/HELLP ITP Others TMA Gestational thrombocytopenia/HT solution (8 mcg/ml) in a standard rate of 15 ml/h and a rapid 1,000 mL crystalloid (Lactated Ringer's solution) cohydration were intravenously administered. The parturient was transferred to the post anesthesia care unit (PACU) for post-operative monitoring, where she remained for 60 minutes. She was transferred back to the ward after full mobilization of legs and stable vital signs
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