Abstract

Perioperative β-blocker therapy has been associated with increased risk of stroke. In this issue of ANESTHESIOLOGY, McKenzie et al. test the hypothesis that there will be no association between preoperative β-blocker initiation within 60 days of surgery or chronic β-blockade and the risk of stroke in patients undergoing major abdominal surgery. In an accompanying editorial, Spence and Kheterpal address the questions surrounding β-blockers and highlight the critical role of large, well–executed randomized controlled trials in patient care. Cover illustration: A. Johnson, Vivo Visuals Studio.

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