ANESTHESIOLOGY IN THE LIGHT OF THE TRANSFORMATIONS OF THE THEORY OF STRESS AND ADAPTATION. PERSPECTIVE OR SKEPTICISM OF PRACTICAL USE? (literature review)

Abstract

The article attempts to analyze the main modern transformations of the theory of stress and adaptation and the possibility of implementing anti-stress adaptation reactions of general anesthesia. One of the central non-specific mechanisms of stressor injury has been found to be the stimulation of free-radical processes as a result of the often concomitant hypoxemia / hypoxia and the prooxidant effects of catecholamines. Data on the regulatory and adaptive effect of FR products (AOS and nitrogen) in the regulation of gene expression and increased production of antistress proteins, stimulation of mitochondrial biogenesis and normalization of energy metabolism are presented. The discussions of the "apologists" of adaptology about the "integral" indicators of the type of adaptation and the functional state of the organism are given. Emphasis is placed on the anesthesiologist's understanding that the organism is a relatively open selforganizing and self-structured dissipative system, as well as a critical view of the mathematical method of evaluating adaptation processes in the organism.