Anesthesia with target-controlled infusion of propofol in endoscopic retrograde cholangiopancreatography

Abstract

Objective To compare the anesthetic effects of propofol using target -controlled infusion (TCI) with that using constant-speed infusion in endoscopic retrograde cholangiopancreatography (ERCP) anesthesia. Methods Sixty seven patients undergoing ERCP were randomly divided TCI group(n=35) and constant-speed group(n=32). Fentanyl(1 μg/kg) was intravenously injected at the beginning of anesthesia for both groups. Then propofol was infused to get the plasma concentration of 3 μg/ml～6 μg/ml in TCI group, and reduced the infusion speed to halve the plasma concentration when duodenoscopy was successfully inserted. Increasing or decreasing 0.5 mg/L propofol deepened or reduced anesthesia depth when necessary. For the constant-speed group, all patienff were inducted by 1.5 mg/kg ～2.5 mg/kg propofol I.v. Manually till eye lash reflex disappeared, then continued by 6 mg·g~(-1) h~(-1)～9 mg·g~(-1)h~(-1) propofol after duodenoscopy inserted. Depth of anesthesia was adjusted by body movements in both groups. Data such as total dosage of propofol, operation time, time for falling asleep, recovery time, adverse events incidence, satisfaction degree of the patients and operaters were recorded and treated by statistics analysis. Results There were less respiratory depression and more satisfaction degree of operaters in TCI group. The difference had statistical significance (P＜0.05). Conclusion Target control infusion of propofol in ERCP anesthesia is easy, has lower incident of respiratory depression and the numeric value of target concentration makes experience exchange convenient. Key words: Propofol; TCI; ERCP