Anemia of inflammation in patients with colorectal cancer: Correlation with interleukin-1, interleukin-33 and galectin-1.

Miodrag Jocić,Nataša Zdravković,Nebojša Arsenijević,Marina Jovanović,Milena Jurišević,Veljko Marić,Ivan Jovanović,Nevena Gajović,Milan Jovanović

doi:10.5937/jomb0-30135

Miodrag Jocić, Nataša Zdravković + Show 7 more

Open Access

https://doi.org/10.5937/jomb0-30135

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Abstract

BackgroundPatients with colorectal cancer (CRC) have anemia often present as a consequence of chronic bleeding from tumor. The exact role of lL-33, Galectin-l and IL-l in the pathological genesis of anemia in colorectal cancer patients has not been elucidated yet. The main goal of this research was to analyze Gal-l, IL-l and lL-33 systemic values in anemic and non-anemic CRC patients.MethodsConcentrations of IL-33, Galectin-1 and IL-1 have been studied in blood samples of 55 CRC patients (27 without anemia and 28 with anemia).ResultsCRC patients with anemia had more severe and local advanced disease compared to CRC non-anemic patients. Anemia positively correlated with higher nuclear grade, lymph and blood vessel invasion, as well as with higher TNM stage, detectable metastatic lesions in lung and liver and peritoneal carcinomatosis. Significantly higher IL-33, Gal-1 and IL-1 concentration have been found in sera of patients with CRC and detected anemia. CRC patients mostly had microcytic anemia, while ferritin values were in normal range. Analysis revealed positive mutual correlation between serum values of galectin-1, IL-1 and IL-33 in CRC patients. Level of hemoglobin negatively correlated with serum IL-33, Gal-1 and IL-1. We have analyzed the Receiver Operating Characteristic (ROC) curves of serum IL-33, Gal-1 and IL-1 showed that these cytokines can be treated as additional markers for anemia of inflammation in CRC patients.ConclusionsPredomination of Galectin-1, IL-1 and IL-33 in anemic CRC patients implicates on their potential role in anemia genesis and further development.

Highlights

colorectal cancer (CRC) is the second most often cause of death from malignancy in the world
Anemia can be caused during systemic inflammatory response to the tumor with higher concentrations of inflammatory cytokines such as interferon gamma (IFN-g), different sorts of interleukins (IL-1, IL-6, IL-8 and IL-10) and tumor necrosis factor alpha (TNF-a) that directly or indirectly stimulate progression of anemia [3, 7]
It is possible that predomination of microcytic anemia in CRC patients suggests on possible gastrointestinal bleeding

Summary

Introduction

CRC is the second most often cause of death from malignancy in the world. Several studies have reported an association between anemia, both microcytic or normocytic, and poorer cancer specific survival of patients due to systemic inflammation and nutritional status [5, 6]. Anemia in CRC patients is often the consequence of chronic bleeding from the tumor; which can be occult from a right colon tumor or visible presence of blood in feces from left colon or rectal cancers [4]. Anemia can be caused during systemic inflammatory response to the tumor with higher concentrations of inflammatory cytokines such as interferon gamma (IFN-g), different sorts of interleukins (IL-1, IL-6, IL-8 and IL-10) and tumor necrosis factor alpha (TNF-a) that directly or indirectly stimulate progression of anemia [3, 7]

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