Abstract
The aim of this study was to evaluate whether anemia identified earlier than 3 months postengraftment in modern era could be predictive of anemia at 12 months. Cross-sectional and cohort studies based on retrospective analysis of existing clinical records were performed. Data on recipient's age at transplantation, follow-up serum creatinine (SCR) and hemoglobin (Hb) on day 7 (D7), at month 1 (M1) and at month 3 (M3) postengraftment were collected. Outcome was anemia identified at 12 months (M12) postengraftment. There were 75 patients on D7, 74 at M1 and 61 at M3. Multiple linear regression model that included recipient's age at transplantation, Hb and creatinine on D7 and tested the risk for anemia at M12 retained only the age in the model, with the coefficient of 0,84 (P=0,001). The same model at M1 retained Hb and age, with the coefficients of 0,26 (P=0,03) and 0,81 (P=0,0002), respectively and at M3 it retained Hb and age, with the coefficients of 0,41 (P=0,004) and 0,70 (P=0,003), respectively. Anemia identified at M1 after renal transplantation is predictive of anemia at M12.
Highlights
MethodsWe conducted cross-sectional and cohort studies based on retrospective analysis of existing clinical records at the University-based Internal medicine hospital in the town of Tuzla, Bosnia and Herzegovina
It takes months after renal transplantation to evaluate renal anemia because non-renal reasons, such as perioperative blood loss, frequent phlobotomies and fluid shifts interfere with its proper evaluation up until months postengraftment ( )
In the early post-transplant period anemia assessment that can be attributed to renal reasons is not reliable because the perioperative blood loss, frequent phlobotomies and fluid shifts interfere with its proper evaluation ( )
Summary
We conducted cross-sectional and cohort studies based on retrospective analysis of existing clinical records at the University-based Internal medicine hospital in the town of Tuzla, Bosnia and Herzegovina. Inclusion criteria Data were collected from the records of patients transplanted and followed up at Tuzla transplant clinic from - and from the records of patients transplanted elsewhere from - , but followed up at Tuzla transplant clinic thereafter. Patients with incomplete or unavailable charts were excluded from the study. The study was approved by a local ethics committee.
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