Abstract
The relation between anemia and inflammatory immune response has lately had much attention. This research was conducted from October 2018 until April 2019, including (110) children below 12 years from both gender in some Hospitals, Primary Health care centers, Public Primary Schools and Kindergarten in Baghdad, Iraq. The objective of this study is to determine the possible correlation between iron deficiency anemia and inflammatory immune response among children infected with Entamoeba histolytica or Giardia lamblia. Blood samples were taken from all groups to measure hemoglobin level, serum iron, total iron binding capacity (TIBC), mean corpuscular volume (MCV), and mean corpuscular hemoglobin concentration (MCHC), while the inflammatory related immune response was evaluated by measuring IL-6 and ferritin. Student T-Test was used to compare between means. The results showed that both hemoglobin and iron concentrations were significantly (P) ˂ 0.01 lower in infected children compared with control, as well as both IL-6 and ferritin levels were significant where (P) ˂0.05 amplified among infected children compared to control. Microcytic hypochromic anemia was observed in the majority of infected children, while normocytic normochromic RBCs was recorded in the majority of control children.
Highlights
Childhood anaemia is a condition where a child has abnormal and insufficient hemoglobin level to provide adequate oxygen to the body tissues 1
Little is known about the relation between gastro intestinal parasites and inflammatory immune response especially in anemic children.The objective of this study is to determine the possible correlation between iron deficiency anemia and inflammatory immune response among children infected with E. histolytica or G. lamblia in Baghdad- Iraq
The mean ±SE of serum iron 34.2±3.42μg/dl was significantly (p) ˂ 0.01 lower in children infected with intestinal protozoan parasites compared with high level of serum iron 67.28±4.51μg/dl in control group
Summary
Childhood anaemia is a condition where a child has abnormal and insufficient hemoglobin level to provide adequate oxygen to the body tissues 1. Anemia in children is considered as global public health challenge which is often numerous potential etiologies[2] but the major frequent cause of anemia globally is Iron Deficiency Anemia (IDA)[3]. IDA anemia is the most public micronutrient deficiency that affects nearly 35% of the world’s population and 1.2 billion individuals worldwide 4,5. Many influences contribute to anemia which are raising energy outflow, irregularly eating habit, poor maternal attention, and acquired infection mainly intestinal parasitic infections showed to be very common among school children[6] Intestinal parasites infection and their prevalence remain among the major health problems especially in the developing countries. Reported that about 3.5 billion people worldwide are still affected by intestinal parasitic infections[7].
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