Anemia and its association with Helicobacter pylori infection among adult dyspeptic patients attending Wachemo University Nigist Eleni Mohammad Memorial Referral Hospital, Southwest Ethiopia: A cross-sectional study.

Kassahun Haile,Girum Tesfaye,Admasu Haile,Abebe Timerga,Tilahun Yemane,Deneke Wolde,Sanjiv Mahadeva

doi:10.1371/journal.pone.0245168

Kassahun Haile, Girum Tesfaye + Show 5 more

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https://doi.org/10.1371/journal.pone.0245168

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Journal: PloS one	Publication Date: Jan 14, 2021
Citations: 8	License type: CC BY 4.0

Affiliation: Wolkite University, Jimma University, Wachemo University

Abstract

BackgroundAnemia is a worldwide public health problem and also associated with Helicobacter pylori (H. pylori) infection. Determining the association of anemia with H. pylori infection is important to develop evidence-based decision and intervention strategies, which is not well known in Ethiopia. Thus, this study aimed to determine the association between anemia and H. pylori infection among adult dyspeptic patients attending Wachemo University Nigist Eleni Mohammad Memorial Referral Hospital in Southwest Ethiopia.MethodsA cross-sectional study was conducted from January to April 2019 involving 362 consecutive adult dyspeptic patients who came to the hospital during the study period. Socio-demographic, clinical and other related data were collected by structured questionnaires. Four milliliters of the venous blood sample was collected for hematological parameters analysis and blood film preparation. A stool sample was collected to detect H. pylori antigen and intestinal parasites. Data were analyzed by SPSS version 21. Logistic regression analyses were performed and p-value <0.05 was considered as statistically significant.ResultsThe overall prevalence of anemia among dyspeptic patients was 24.3% (95%CI: 19.9–28.7). Among H.pylori infected participants 29.2% were anemic, of which 69.2% had mild anemia and 63.5% had normocytic normochromic anemia. Rural residence (AOR: 1.9, 95%CI: 1.1–3.3), H. pylori infection (AOR: 1.77, 95%CI: 1.05–2.98) and intestinal parasitic infection (AOR: 2.14, 95%CI: 1.14–4.03) were significantly associated with anemia.ConclusionThe prevalence of anemia in this study indicated that it is a moderate public health problem. Rural residence, H. pylori and intestinal parasitic infection were significantly associated with anemia. The findings of this study should be taken into account for the prevention and control of anemia among dyspeptic adults.

Highlights

Anemia is a global public health problem affecting both developed and developing countries [1]
Rural residence (AOR: 1.9, 95% confidence interval (CI): 1.1–3.3), H. pylori infection (AOR: 1.77, 95%CI: 1.05–2.98) and intestinal parasitic infection (AOR: 2.14, 95%CI: 1.14–4.03) were significantly associated with anemia
The prevalence of anemia in this study indicated that it is a moderate public health problem

Summary

Introduction

Anemia is a global public health problem affecting both developed and developing countries [1]. A study reported a 32.9% global burden of anemia in all ages combined, Sub-Saharan Africa shared the highest-burden [2]. It has serious implications for health, as well as social and economic development [3]. It increases susceptibility to infections, impairs the physical capacity and work performance of the adults [4, 5] It is a significant public health problem in Ethiopia, according to a national report of 2016, 24% of women and 15% of men were anemic [6]. This study aimed to determine the association between anemia and H. pylori infection among adult dyspeptic patients attending Wachemo University Nigist Eleni Mohammad Memorial Referral Hospital in Southwest Ethiopia

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