Abstract
A change in androgen content of spermatic vein blood of anesthetized dogs after luteinizing hormone (LH: NIH-LH-B3) administration was studied using gas-liquid chromatography. A definite increase in content of androstenediol as well as testosterone, androstenedione and dehydroepiandrosterone was noted. Androstenediol was identified by several chromatographic procedures and by infrared spectroanalysis. In situ and in vivo perfusion study revealed the conversion of dehydroepiandrosterone-4-11C to androstenediol-14C and testosterone-14C, and that of androstenediol-3H to testosterone-3H by the dog testis. Perfusion of androstenedione-4-14C or testosterone-4-14C via the spermatic artery produced no demonstrable androstenediol-14C in canine spermatic vein blood. These findings strongly support the view that androstenediol is one of the important intermediates in testosterone biosynthesis by dog testis. (Endocrinology 83: 992, 1968)
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