Abstract
Treatment of poor-responder patients to controlled ovarian stimulation is a challenge in reproductive technology. ObjectiveTo evaluate some synergistic effects in folliculogenesis by improving the ovarian sensitivity to FSH (Follicle Stimulating Hormone) and follicular response to gonadotrophins. MethodA literature review that evaluated the use of androgens in ovarian response of pretreatment of ovarian stimulation on low-responder IVF (In Vitro Fertilization) patients. ResultsThe most articles showed an increase on ovarian response in patients who used transdermic testosterone before ovarian stimulation. Those women achieved greater number of recovered oocites and more mature ones in women who used transdermal testosterone. In addition, it increased clinical pregnancy and live birth rates. Women who received DHEA (dehydroepiandrosterone), aromatase inhibitors, rLH (recombinat luteinizing hormone) or rhCG (recombinant gonadotropin releasing hormone) showed no significant differences in studied parameters. ConclusionPretreatment with transdermal testosterone seems to be beneficial to ovarian response on poor-responder patients. It has increased clinical pregnancy and live birth rates. There were no benefits with use of rLH, hCG, DHEA or aromatase inhibitors proved in those studies.
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