Abstract
Testosterone, 5α-dihydrotestosterone and cyproterone acetate (CPA)_were estimated in samples of prostate tissue, obtained from benign prostatic hyperplasia (BPH) patients who were or were not pretreated with CPA. Furthermore, these steroids were estimated in various fractions of the BPH tissue, and the number of nuclear androgen-receptor sites was determined. CPA-treatment caused a 4-fold, significant suppression of 5α-dihydrotestosterone levels in total prostate tissue and its subfractions, without affecting testosterone levels or the androgen-receptor contents of the nuclear extracts. Nuclear concentrations of CPA were twice as high as those of 5α-dihydrotestosterone. It is conclude that effects of CPA may have been caused through a combination of the following mechanisms: (1) suppression of peripheral androgen levels: (2) competition with androgens for (nuclear) androgen-receptors; and (3) suppression of prostatic 5α-reductase.
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