Abstract
The degree to which various androgens increase anogenital distance in the female rat fetus and the degree of antagonism of this androgenic action by simultaneous administration of the antiandrogen cyproterone acetate, have been determined. The virilizing potency in order of decreasing effectiveness is dihydrotestosterone (DHT), 5α-androstan-3α,17β-diol (3α-diol), testosterone, androst-4-en-3,17-dione, 5α-androstane, 3β,17β-diol, androst-5-en-3β-ol-17-one and androsterone. The androgens, except 3a-diol, also reduce fetal adrenal weight, while cyproterone acetate prevents this effect. DHT and 3α-diol correct the degree of hypospadias produced by cyproterone acetate in male fetuses to a greater degree than testosterone but the antiandrogen blocks the androgenic action of the testosterone metabolites more than it does testosterone. These results suggest that the metabolites of testosterone can be responsible for the organizing action of testosterone in the fetus. (Endocrinology89: 276, 1971)
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