Abstract
Summary Application of a novel method for microestimation of 5′-deoxy-5′-methylthioadenosine disclosed that several rat tissues (including ventral prostate which accumulates and secretes large amounts of spermidine and spermine) contain this nucleoside in concentrations of less than 7 nmol per g wet weight. Orchiectomy results in significant decline in methylthioadenosine phosphorylase activity in the ventral (but not the anterior) prostate of adult rats which is reversed by testosterone treatment. Changes in methylthioadenosine concentrations in ventral prostate due to variations in androgenic status are only minor in comparison with alterations in polyamine metabolism.
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