Abstract
Spermatogenesis is an androgen dependent process which can be maintained in hypophysectomized rats by the administration of either testosterone (1) or 5α-dihydrostestosterone (2). Gonadotrophins may exert their effects on spermatogenesis indirectly by way of androgens. The sole action of LH appears to result from the stimulation of testosterone synthesis by the interstitial cells of Leydig. FSH is necessary for the full maintenance of spermatogenesis, but its effects can be mimicked by androgen and blocked by the anti-androgen, cyproterone, indicating that its action is linked in series with androgen (1) or that androgen is the mediator of FSH action.
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