Androgen Support and Erectile Function in Men with Diabetes Mellitus Type 2 and Obesity

Abstract

The objective: to study to determine state of erectile function and androgen support in men with diabetes mellitus type 2 and obesity.Materials and methods. A total of 56 men aged 35 to 65 years old were examined from CD2 (38 with obesity (group I) and 18 without obesity (group II)) and 82 healthy men who formed a control group. In blood, the concentration of follytropin (FSH), lutropin (LH), total testosterone (Ttot), testosterone free (Tfree), estradiol (E2), sex steroid binding globulin (SSBH) and prolactin (PRL) were determined by immunoferment method. The obesity criterion was considered as body mass index (BMI) >30 kg/m2. The state of erectile function was investigated using the International Index of Erectile Function Questionnaire (IIEF-15).Results. The average blood serum levesl of Ttot and Tfree in both groups of patients were lower thsn in the control group. The average levels of estradiol in blood of , Group I patients were significantly higher compared to patients in Group ІІ. The average levels of pituitary hormones: FSH, LH and PRL in the patients of both examined groups were not significantly different from those in control group. The results of MIEF-15 inmen with type 2 diabetes and androgen deficiency revealed a marked decrease in all indicators of erectile function in the examined groups compared with the control ones. A more pronounced decrease in integrative indexes of MIEF-15 questionnair were in the subjects with obesity.Conclusions. The obtained data (reduction of erectile function, orgasm, libido) indicate the presence of a violation of the hormonal component of the regulation of the sexual function in men with type 2 diabetes and obesity.