Androgen-regulated proteins in the rat ventral prostate: Androgen-regulierte Proteine der ventralen Rattenprostata

Abstract

The rat ventral prostate synthetizes and secretes a number of relatively abundant proteins, such as Prostatic Binding Protein (PBP), the Proline-Rich Polypeptides (PRP), the 20 or 22-kDa protein and a prostatic protease, which respectively constitute approx. 50, 5, 10 and 2% of the secreted protein. The synthesis of these proteins is androgen-regulated and this is also the case for the concentration of the corresponding mRNAs. The existence of a putative androgen response element in the first intron of the PBP-C3 gene supports the possibility of a direct control of its transcription by androgen receptor complexes, but there is also evidence for the requirement of protein synthesis for mRNA stimulation. Finally, changes of tissue composition and cell-cell interactions between epithelial and stromal cells most probably play an important role in the global effect of androgens on the rat ventral prostate.