Androgen receptor CAG repeat length polymorphism in benign prostatic hyperplasia (BPH): Correlation with adenoma growth

Abstract

BACKGROUND The androgen receptor (AR) gene has a polymorphic CAG microsatellite encoding variable-length glutamine repeats in the AR protein. The purpose of this study was to evaluate the association between the growth of benign prostatic hyperplasia (BPH) and the AR gene CAG repeat length. METHODS We determined CAG repeat lengths in 176 BPH patients who underwent simple prostatectomy and in 41 control subjects without benign prostatic enlargement (non-BPE group). RESULTS A statistically significant (P < 0.02) trend for large adenoma size with short CAG repeat length was found among the adenoma quartiles. CAG repeat length in the fourth quartile (large adenoma, 21.5 ± 2.7) was significantly shorter than in the first quartile (small adenoma, 23.3 ± 2.1, P < 0.02). It tended to be shorter than in the non-BPE group (23.1 ± 2.4), but CAG repeat lengths in the entire BPH (22.4 ± 2.5) and non-BPE groups did not significantly differ. The relative risk of large BPH (the fourth quartile) was 2.75 (95% confidence interval, 1.05–7.24; P < 0.05) on comparing CAG repeats of ≤22–≥23. CONCLUSIONS Shorter CAG alleles may be a genetic factor that promotes the growth of BPH. Prostate 41:253–257, 1999. © 1999 Wiley-Liss, Inc.