Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma.

Yongxiang Shi,Qinghuai Li,Zhaoming Ye,Weishan Chen

doi:10.18632/oncotarget.11902

Yongxiang Shi, Qinghuai Li + Show 2 more

Open Access

https://doi.org/10.18632/oncotarget.11902

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Journal: Oncotarget	Publication Date: Sep 8, 2016
Citations: 1	License type: cc-by

Affiliation: Zhejiang University

Abstract

The androgen receptor (AR) is involved in the differentiation and growth of many cancers. We hypothesized that two microsatellite polymorphic variants, AR (CAG)n and (GGN)n repeats, were also associated with the development of Papillary thyroid cancer (PTC) and Osteosarcoma. In current study, we conducted two case-control studies in a Chinese population to investigate the possible relationship between these two AR repeat polymorphisms and the risk of PTC and Osteosarcoma. The AR CAG repeat length was significantly associated with both risk of PTC and Osteosarcoma. Subjects with shorter AR CAG repeats had a higher risk of developing PTC (OR = 1.47, 95% CI: 1.17–1.85, P = 0.001) and Osteosarcoma (OR = 1.53, 95% CI: 1.19–1.97, P = 9.2 × 10–4). Specifically, shorter GGN repeats also contribute a significant increased risk of Osteosarcoma (OR = 1.35, 95% CI: 1.03–1.77, P = 0.030). Our results contribute to a better understanding of the complex hormone related mechanisms underlying PTC and Osteosarcoma.

Highlights

C Our results contribute to a better understanding of the complex hormone related mechanisms underlying Papillary thyroid cancer (PTC) and Osteosarcoma
To the best of our knowledge, this is the first report to attempt an evaluation of the associations of androgen receptor (AR) repeats length potentially related to PTC and Osteosarcoma carcinogenesis
We identified that subjects with shorter AR repeats length contributed to higher risk of developing PTC and Osteosarcoma, either as continuous variable or a categorical variable, which indicating the robustness of the results in current study

Summary

RESULTS

Characteristics of the studied population associated with a more aggressive phenotype of small T1 differentiated thyroid cancers (DTC). E CAG and GGN polymorphisms and PTC risk We first analyzed the AR repeats length as continuous. Shorter AR GGN repeats didn’t show a significant association with the risk of PTC (P value > 0.05). C length was analyzed as categorical variables, and the median value 22, 23 were selected as cut-points for the CAG repeat and the GGN repeat, respectively. A, compared to those with the longer (≥ 22) CAG repeat length, subjects in the category of shorter (< 22) CAG repeats had a significant 47% increased risk of PTC (OR = 1.47, 95% CI: 1.17–1.85, P = 0.001). P = 0.029) contribute to higher risk of Osteosarcoma Table 3 Compared to those with the longer (≥ 22) CAG

DISCUSSION

E Table 3

MATERIALS AND METHODS

A Statistical analyses