Abstract
e16131 Background: The use of androgen deprivation therapy (ADT) has been associated with an increased risk of venous thromboembolism (VTE) in patients with prostate cancer, but data remain limited. Methods: A population-based cohort of 21,729 men newly-diagnosed with prostate cancer between 1998 and 2014 was identified using the United Kingdom Clinical Practice Research Datalink linked to the Hospital Episode Statistics database. Time-dependent Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) of hospitalized VTE associated with current and past ADT use, compared with non-use. A secondary analysis was conducted to assess the risk with current use of specific types of ADT. Results: During a mean follow-up of 4.1 years, there were a total of 609 hospitalized incident VTEs. Compared with non-use, current ADT use was associated with a two-fold increased risk of VTE (incidence rates: 10.1 vs 4.8 per 1000 persons per year; HR: 1.99; 95% CI: 1...
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