Abstract
To clarify the degradation pathway of acrinol by light, isolation and identification of acrinol degradation products (ANDP) were attempted. A novel acrinol degradation product, ANDP-7, one of the ANDPs, was isolated by extraction with methanol from cloths dampened with acrinol solution, and purified by column chromatography on Diaion HP-10 and Sephadex LH-20. The structural elucidation of ANDP-7 was examined by 1H-NMR, 13C-NMR and EI-mass spectra sudies. From the spectroscopic data, the structure of ANDP-7 was determined to be 9-amino-7-ethoxypyrrolo[3,4-b]quinoline-1,3-dione, that was found to be a novel degradation product of acrinol by light. Antimicrobial activities of ANDP-7 against Gram-positive and -negative bacteria were 5 to 100-fold higher than those of acrinol. ANDP-7 was also active against yeast and fungi. Nevertheless, acrinol did not show growth inhibition even at a concentration 100 μg/ml.
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