Abstract
Andosan™ is an extract prepared from medicinal Basidiomycetes mushrooms, mainly Agaricus blazei Murill (AbM) (82%), but it also contains Hericeum erinaceus (He) (15%) and Grifola frondosa (Gf) (3%), all of which have immunomodulating properties. Whereas He and Gf have been used in traditional Chinese and Japanese medicine against cancer, AbM originates from Brazilian rain forest and was used locally and later abroad as health food for the prevention of a range of diseases, including chronic hepatitis, diabetes and cancer. The mushrooms’ health effects are probably due to their content of A¯Â¢-glucans and other smaller immunomodulating polysaccharides and proteoglucans. These effects are mediated through their stimulation of innate immune cells, such as monocytes, NK cells and dendritic cells, and the amelioration of a skewded Th1/Th2 balance and of inflammation. Here, we give an overview of the anti-allergic effects of Andosan™ in a mouse model for allergy and anti-inflammatory effects both in vitro, in healthy individuals and in patients with inflammatory bowel diseases.
Highlights
Atopy is a condition where the immune system reacts to common substances in the environment with a genetically determined overproduction of allergen specific antibodies of IgE isotype
Our report agrees with Agaricus blazei Murill (AbM)-induced anti-inflammatory and antiallergic effects found in mouse bone marrow-derived mast cells [71], the inhibitory effect on mast cell-mediated anaphylaxis-like reactions in mice [72], and the amelioration of skewed Th1/Th2 balance in asthmatic [66] and allergic mice [52]
It disagrees with reports on proatherogenic and proinflammatory effects of AbM in a mouse model for atherosclerosis [73] and a clinical randomized trial that found no immunomodulatory effect in elderly women who received dried AbM extract [74]
Summary
Atopy is a condition where the immune system reacts to common substances in the environment (allergens) with a genetically determined overproduction of allergen specific antibodies of IgE isotype. We give an overview of the anti-allergic effects of AndosanTM in a mouse model for allergy and anti-inflammatory effects both in vitro, in healthy individuals and in patients with inflammatory bowel diseases.
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