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Abstract
A new tool for genome-wide definition of genomic gene clusters conserved in multiple species was applied to olfactory receptors in five mammals, demonstrating that most mammalian olfactory receptor clusters have a common ancestry.
Highlights
Mammalian olfactory receptor (OR) genes reside in numerous genomic clusters of up to several dozen genes
OR genomic mining in opossum and dog For the OR gene repertoire of the opossum Monodelphis domestica, we mined a total of 1,518 ORs from the Opossum October 2004 assembly
For CLICs that do not contain human clusters, the human location that is syntenic to the region of the mouse OR cluster was considered
Summary
Mammalian olfactory receptor (OR) genes reside in numerous genomic clusters of up to several dozen genes. Olfactory receptor (OR) genes constitute the largest superfamily in the vertebrate genome, with several hundred genes per species [1,2,3]. This large repertoire of receptors mediates the sense of smell through the recognition of diverse volatile molecules, used to detect food, predators, and mates. The combination of synteny data and sequence similarity has been used to map between the majority of human and dog clusters, indicating their common origin [11]. Thirteen dog clusters that could not be mapped were suggested to be 'dog specific'
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