Abstract
The emergence of high-throughput sequencing techniques and the development of bioinformatics tools provide efficient ways to profile the human adaptive immune receptor repertoire (AIRR) including repertoires of T cell receptors (TCRs) and immunoglobulins (Bradley and Thomas, 2019). Despite these advancements, the representation of populations in the AIRR sequencing (AIRR-seq) studies remains unknown. AIRR data from populations with diverse genetic ancestry could potentially elucidate genomic and phenotypic similarities or differences in the human immune system and immune-related diseases across populations (Peng et al., 2021).
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