Abstract
We report herein on two cases of ANCA-associated middle ear disease. Case 1: A 31-year-old female first complained of left earache and left aural obstruction with an increase in serum levels of PR3-ANCA. Case 2: A 78-year-old female first complained of bilateral ear discharge and hearing loss with an increase in serum level of MPO-ANCA. In both cases, we clinically suspected ANCA-associated middle ear disease and administered steroids and an immunosuppressant. In case 1, the patient was making steady progress as regards the local symptoms. In case 2, bilateral facial paralysis had developed two months after the start of the therapy. In neither case did aggravation of the general symptoms develop.In the treatment of ANCA-associated middle ear disease, we must follow up carefully long enough to prevent development of hearing loss and facial paralysis.
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