Anatoxins and Anatoxic Immunizations—Diphtheria and Tetanus Immunizations: Results of Thirty Years' Application in the World.

Abstract

This booklet is a review of the development of the anatoxins of diphtheria and tetanus by their discoverer, G. Ramon. It is these anatoxins, now called toxoids, that are used throughout the world today. Their use has practically eliminated diphtheria and tetanus in immunized peoples. The author begins his review with the discovery of diphtheria toxin by Emile Roux, in 1888, and proceeds through the development of diphtheria antitoxin and the toxin-antitoxin mixture. His own work on diphtheria and tetanus toxoids is summarized, as well as the effects of immunization with these products on the morbidity and mortality of diphtheria and tetanus since their use in 1923. It is a short factual history. The material comprising this booklet was given before the sixth International Congress for Microbiology, Rome (Sept. 6 to 12, 1953) by G. Ramon. It was dedicated to the memory of Emile Roux, in commemoration of the hundredth