Anatomically based targeting of prefrontal cortex for rTMS

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is an efficacious treatment for major depressive episodes.1 Most clinical applications of this technology are based on probabilistic targeting methods that do not account for individual anatomic variability (eg, the so-called “5-cm rule”) or factor primarily the skull and not brain size differences (eg, using the International 10-20 EEG system).2,3 This may lead to suboptimal clinical responses when compared with individualized targeting techniques based on structural brain scanning.