Anatomically and functionally constrained MEG/EEG source estimates: Theoretical background and practical implementation

Abstract

Event Abstract Back to Event Anatomically and functionally constrained MEG/EEG source estimates: Theoretical background and practical implementation Matti S. Hamalainen1* 1 University of Georgia, Department of pharmacology and physiology, United States Independently, electromagnetic and hemodynamic measurements of brain activity offer compromises between spatial and temporal resolution. Functional Magnetic Resonance Imaging (fMRI) is temporally limited by the slow time course of the hemodynamic response, but can provide a spatial sampling on a millimeter scale. Electroencephalography (EEG) and magnetoencephalography (MEG) in turn provide a temporal resolution of milliseconds, but the localization of sources is more complicated because of the ill-posed electromagnetic inverse problem. This presentation will cover the theoretical and technical background of MEG/EEG source estimation with emphasis on the weighted l2-norm solutions and on the use of anatomical and fMRI data to constrain the solutions. In addition, our novel sparse but temporally smooth l1l2-norm approach as well as our recently proposed fMRI-Informed Regional EEG/MEG source Estimation (FIRE) will be discussed. The region-based approach makes FIRE computationally efficient and comparisons with several joint fMRI-EEG/MEG algorithms demonstrate the robustness of FIRE in the presence of sources silent to either fMRI or EEG/MEG measurements. Acknowledgments: This work is supported by the NIH grants P41-RR14075 (NCRR), 1R01EB009048-01 (NIBIB), and 5R01EB006385-03 (NIBIB) Conference: NeuroMath COST Action BM0601: Neurodynamic Insight into Functional Connectivity, Cognition, and Consciousness, Dubrovnik, Croatia, 27 Mar - 28 Mar, 2010. Presentation Type: Oral Presentation Topic: Talks Citation: Hamalainen MS (2010). Anatomically and functionally constrained MEG/EEG source estimates: Theoretical background and practical implementation. Front. Neurosci. Conference Abstract: NeuroMath COST Action BM0601: Neurodynamic Insight into Functional Connectivity, Cognition, and Consciousness. doi: 10.3389/conf.fnins.2010.05.00001 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Jul 2010; Published Online: 24 Jul 2010. * Correspondence: Matti S Hamalainen, University of Georgia, Department of pharmacology and physiology, Athens, United States, msh@nmr.mgh.harvard.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Matti S Hamalainen Google Matti S Hamalainen Google Scholar Matti S Hamalainen PubMed Matti S Hamalainen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.