Anatomical Structures Object Library of the Human Reference Atlas

Abstract

The Human BioMolecular Atlas Program (HuBMAP) aims to create a computable, open Human Reference Atlas (HRA) [1]. This HRA will redefine our understanding of the human body by recovering multi‐scale tissue organization from the human body to the single cell resolution. In the initial three years of the project, we created an authoritative ontology of anatomical structures, cell types, and biomarkers; this anatomical structure terminology was then linked to three‐dimensional reference objects in the size and shape of human organs, functional tissue units, and anatomical micro‐structures [2]. Many of the current 52 reference organs were derived from the Visible Human Project data. An initial subset can be explored at https://hubmapconsortium.github.io/ccf/pages/ccf‐3d‐reference‐library.html. The growing collection of reference objects form the basis of tissue data registration via the Registration User interface (RUI, https://hubmapconsortium.github.io/ccf‐ui/rui); registered tissue data can be explored in the context of the atlas via the Exploration User Interface (EUI, https://portal.hubmapconsortium.org/ccf‐eui).We are in the process of developing standard operating procedures and design style guides for the HuBMAP Reference Object Library and would like to present first drafts of both at the AAA meeting to benefit from feedback by the larger expert community.References Snyder MP, Greenleaf WJ, Ahadi S, Nevins SA, Lee H, Esplin E, et al. The human body at cellular resolution: the NIH Human Biomolecular Atlas Program. Nature 2019; 574:187–92. Börner K, Teichmann SA, Quardokus EM, Gee JC, Browne K, Osumi‐Sutherland D, et al. Anatomical structures, cell types and biomarkers of the Human Reference Atlas. Nat Cell Biol 2021; 23:1117–28. https://doi.org/10.1038/s41556‐021‐00788‐6.