Anatomical location of polypoidal choroidal vasculopathy lesions inferred from simultaneous ICGA‐OCT

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AbstractPurpose To identify the spatial location of polypoidal choroidal vasculopathy (PCV) lesions including branching vascular network (BVN) and late geographic hyperfluorescence (LGH).Methods This retrospective study involved 15 eyes (15 subjects) affected by active PCV. Utilizing innate software for simultaneous indocyanine green angiography (ICGA) and optical coherence tomography (OCT), we identified the corresponding tomographic locations of BVN and LGH on ICGA.Results LGH was noted in 9 eyes, and the extent of LGH was the same (5 eyes) as or larger (4 eyes) than the extent of BVN. The extent of ‘double layer sign’ on OCT coincided exactly with the extent of LGH on ICGA. Image analysis revealed that larger vessels of BVN located not in‐between retinal pigment epithelium and Bruch’s membrane but within choroidal layer.Conclusion This study indicates that, at least, a part of BVN locates within choroidal layer. And the tomographic location of the lesion corresponding to LGH lies above Bruch’s membrane. The origin of LGH would be fluorescein staining of the lesion above Bruch’ membrane, possibly due to exudation from BVN.