Abstract
Using retrograde transport of Fluoro-Gold (FG) combined with immuncfluorescence for phenylethanolamine- N-methyltransferase (PNMT), we have examined afferents to the nucleus locus coeruleus (LC) from the rostral ventrolateral medulla (nucleus paragigantocellularis; PGi) in rats sustaining lesions of the medullary adrenergic bundle (MB). In lesioned rats, very few adrenergic LC-projecting neurons persist in the PGi ipsilateral to the lesion, representing a 90% decrease in comparison to non-lesioned animals. These results indicate that almost all adrenergic input to the LC from C1 neurons in PGi is conveyed by the MB. In contrast, the number of non-adrenergic LC afferent neurons in the PGi ipsilateral to the lesion only decreased by 48% after such lesions. Thus, this pathway also provides non-adrenergic projections to LC from PGi, but many of these are conveyed by other route(s) as well.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
