Abstract
Transient receptor potential vanilloid (TRPV) channels are cellular sensors responding to changes in the temperature, mechanical stress and osmolarity. Isoform TRPV2 are Ca2+ permeable cation channels. The neuroanatomical localization and the physiological role of TRPV2 in the rodent brain is unknown. This study utilized immunohistochemistry combined with confocal microscopy to identify the distribution of TRPV2 in rat brain. In the forebrain, TRPV2 immunoreactive (IR) neurons were most robustly expressed in the supraoptic nucleus (SON). IR neurons were observed in the magnocellular neurosecretory cells (MNC) of the paraventricular nucleus (PVN), median preoptic nucleus, and the arcuate nucleus of the hypothalamus, medial forebrain bundle, retrochiasmatic area, the cingulate gyrus, globus pallidus and the caudate putamen. The hindbrain showed most robust immunostaining in nucleus of the solitary tract (NTS), hypoglossal nucleus and rostroventrolateral nucleus. TRPV2 co-localized with the vasopressin (AVP) in MNCs in SON and PVN. Also, TRPV2 was co-localized with dopamine beta-hydroxylase in the NTS, suggesting a homeostatic regulatory role played by TRPV2. Our data indicate that TRPV2 is expressed in brain regions involved in body fluid balance and autonomic control. R01 HL062579.
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