Abstract
There is a non-linear interaction of binaural stimulation on auditory brain-stem potentials in both human and animals. The interaction takes the form of the binaurally evoked ABR being of smaller amplitude than the sum of the monaurally evoked ABRs. In the guinea pig this interaction occurs at the time of components P4, N4 and P5. In order to investigate the generator sites of binaural interaction in the ABR, various lesions were made in the brain-stem auditory system in 29 guinea pigs. The effects of those lesions on binaural interaction were as follows: (1) unilateral lesion of lateral lemniscus or bilatraal lesions of the inferior collculi had no significant effect on binaural interaction; (2) transection of the lateral lemnisci bilaterally was associated with a loss of the component of binaural interaction associated in time with N4; (3) a lesion just lateral to the lateral superior olivary complex resulted in an attenuation of the component of binaural interaction associated in time with P4; (4) complete section of the decussating fibers of the trapezoid body or a complete unilateral lesion of the superior olivary complex led to a loss of all components of binaural interaction. There results suggest that binaural interaction in the guinea pig ABR requires the integrity of several distinct portions of the brain-stem auditory pathway, i.e., both lateral lemnisci are required for the interaction occurring at the time of N4; the brain-stem just lateral to the lateral superior olive participates in the interaction at the time of P4. The trapezoid body and superior olivary nucleus are required for binaural interaction at P4, N4 and P5.
Highlights
The auditory brain-stem responses (ABRs) are well known as early auditory evoked responses occurring within 10 msec after sound stimulus and consist of 7 vertex positive peaks in human (Jewett and Williston 1971; Lev and Sohmer 1972). Jewett (1970) first described binaural interaction in the ABR by showing that the ABR evoked by binaural stimuli differed from the sum of the monaurally evoked responses
The component of binaural interaction associated in time with P4 was reduced by 60% with a smaller reduction of the component of the binaural interaction associated in time with N4 (18%) (Fig. 6)
(2) Bilateral lateral lemniscal lesions were associated with the loss of only the component of binaural interaction associated in time with N4
Summary
The auditory brain-stem responses (ABRs) are well known as early auditory evoked responses occurring within 10 msec after sound stimulus and consist of 7 vertex positive peaks in human (Jewett and Williston 1971; Lev and Sohmer 1972). Jewett (1970) first described binaural interaction in the ABR by showing that the ABR evoked by binaural stimuli differed from the sum of the monaurally evoked responses. The auditory brain-stem responses (ABRs) are well known as early auditory evoked responses occurring within 10 msec after sound stimulus and consist of 7 vertex positive peaks in human (Jewett and Williston 1971; Lev and Sohmer 1972). Jewett (1970) first described binaural interaction in the ABR by showing that the ABR evoked by binaural stimuli differed from the sum of the monaurally evoked responses. Binaural interaction occurs at the time of waves V and VI of the human ABR
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